Pramipexole protective effect on rotenone induced neurotoxicity in mice
نویسندگان
چکیده
Introduction: Pramipexole is a new dopaminergic drug which has been approved for PD treatment. However, we tried to find new capacity for this drug rather than symptomatic effect. Materials and Methods: A chronic rotenone model with daily oral dose of 30mg/kg was induced in mice. Pramipexole was tried in a new approach where the treatment began in the middle of rotenone course with oral dose 1mg/kg /day of pramipexole. Results: Further analysis of behavioral tests and immunohistochemistry revealed success of pramipexole in improving the rotenone intoxicated mice. Conclusion: These results showed possible beneficial effect of pramipexole against rotenone induced neurotoxicity.
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